What question did this study set out to answer?

To determine whether low influenza vaccine effectiveness during the 2012–13 season stemmed from antigenic drift in circulating strains or mutations acquired during egg-based vaccine manufacturing.

March 25, 2014PLoS ONEOpen Access

Low 2012–13 Influenza Vaccine Effectiveness Associated with Mutation in the Egg-Adapted H3N2 Vaccine Strain Not Antigenic Drift in Circulating Viruses

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Authors

DSDanuta M. SkowronskiUniversity of British Columbia NJNaveed Z. JanjuaUniversity of British Columbia GSGaston De SerresCentre hospitalier universitaire de Québec

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Implication

Test-negative case-control study reveals low influenza vaccine effectiveness against H3N2 in outpatients, suggesting egg-adaptation mutations rather than viral drift reduced protection.

Key Points

To determine whether low influenza vaccine effectiveness during the 2012–13 season stemmed from antigenic drift in circulating strains or mutations acquired during egg-based vaccine manufacturing.
Conducted a test-negative case-control study assessing vaccine effectiveness against medically attended, PCR-confirmed influenza across 1,501 participants in Canada.
Characterized influenza A isolates genotypically via haemagglutinin amino acid sequencing and phenotypically through haemagglutination inhibition assays relative to WHO prototype and egg-adapted strains.
Overall vaccine effectiveness was 50% (95% CI: 33–63%), driven down by poor protection against predominant A(H3N2) at 41% (95% CI: 17–59%).
Vaccine effectiveness was 59% (95% CI: 16–80%) against A(H1N1)pdm09, 67% (95% CI: 30–85%) against B/Yamagata, and 75% (95% CI: 29–91%) against B/Victoria.
Circulating H3N2 isolates matched the WHO-recommended prototype but differed antigenically from the egg-adapted vaccine strain, which harbored three amino acid mutations at antigenic sites B (H156Q, G186V) and D (S219Y).

Cite This Study

Skowronski et al. (2014) studied this question.

synapsesocial.com/papers/6a01d8dd950a93c470d8bb7e https://doi.org/10.1371/journal.pone.0092153

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Implication

Test-negative case-control study reveals low influenza vaccine effectiveness against H3N2 in outpatients, suggesting egg-adaptation mutations rather than viral drift reduced protection.

Low 2012–13 Influenza Vaccine Effectiveness Associated with Mutation in the Egg-Adapted H3N2 Vaccine Strain Not Antigenic Drift in Circulating Viruses

Discussion

Member takes

Implication

Key Points

Cite This Study

Low 2012–13 Influenza Vaccine Effectiveness Associated with Mutation in the Egg-Adapted H3N2 Vaccine Strain Not Antigenic Drift in Circulating Viruses

Discussion

Member takes

Implication

Key Points

Cite This Study

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