Targeting KDM1A in Neuroblastoma with NCL-1 Induces a Less Aggressive Phenotype and Suppresses Angiogenesis

Annika Sprüssel; Takayoshi Suzuki; Naoki Miyata; Kathy Astrahantseff; Annabell Szymansky; Joern Toedling; Theresa M. Thole-Kliesch; Annika Ballagee; Marco Lodrini; Annette Künkele; Matthias Truß; Lukas C. Heukamp; Susanne Mathia; Falk Hertwig; Christian Rosenberger; Angelika Eggert; Hedwig E. Deubzer; Johannes H. Schulte

doi:10.3390/jcm13206081

Ask about this paper

Answers are grounded in this paper and cite their sources.

Abstract

: Inhibiting KDM1A could attack aggressive neuroblastomas two-fold, by re-directing tumor cells toward a less aggressive, slower-growing phenotype and by preventing or reducing the vascular support of large tumors.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Sprüssel et al. (2024) studied this question.

synapsesocial.com/papers/6a01d92abd6301933f5cc766 https://doi.org/10.3390/jcm13206081

View Full Paper

Ask AI

Bookmark

Share

Targeting KDM1A in Neuroblastoma with NCL-1 Induces a Less Aggressive Phenotype and Suppresses Angiogenesis

Ask about this paper

Abstract

Discussion

Cite This Study

Targeting KDM1A in Neuroblastoma with NCL-1 Induces a Less Aggressive Phenotype and Suppresses Angiogenesis

Ask about this paper

Abstract

Discussion

Cite This Study

Keep reading

Keep reading