What question did this study set out to answer?

To delineate the mechanisms through which prostaglandin E2 regulates immune cell behavior and mediates immunopathology across chronic infections and cancer.

December 20, 2011The Journal of ImmunologyOpen Access

Regulation of Immune Responses by Prostaglandin E2

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Authors

PKPaweł KalińskiRoswell Park Comprehensive Cancer Center

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Implication

Review demonstrates how prostaglandin E2 suppresses type 1 immunity while expanding regulatory cells in chronic disease, suggesting novel therapeutic targets for cancer and autoimmunity.

Key Points

To delineate the mechanisms through which prostaglandin E2 regulates immune cell behavior and mediates immunopathology across chronic infections and cancer.
Synthesized molecular pathways governing cyclooxygenase 2-mediated synthesis, 15-hydroxyprostaglandin dehydrogenase-mediated degradation, and receptor signaling of prostaglandin E2.
Evaluated the functional consequences of prostaglandin E2 signaling on innate and adaptive immune cell subsets and chemokine expression profiles.
Prostaglandin E2 suppresses acute inflammatory mediators, neutrophil and macrophage effector functions, and type 1 immunity driven by Th1, cytotoxic T, and natural killer cells.
Prostaglandin E2 promotes Th2, Th17, and regulatory T-cell responses while altering chemokine gradients to facilitate local accumulation of regulatory T cells and myeloid-derived suppressor cells.

Cite This Study

Paweł Kaliński (2011) studied this question.

synapsesocial.com/papers/6a01eb811adb974501cb002f https://doi.org/10.4049/jimmunol.1101029

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Implication

Review demonstrates how prostaglandin E2 suppresses type 1 immunity while expanding regulatory cells in chronic disease, suggesting novel therapeutic targets for cancer and autoimmunity.

Regulation of Immune Responses by Prostaglandin E2

Discussion

Member takes

Implication

Key Points

Cite This Study

Regulation of Immune Responses by Prostaglandin E2

Discussion

Member takes

Implication

Key Points

Cite This Study

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