What question did this study set out to answer?

To determine whether dysregulated expression of the spliced transcription factor XBP-1 drives the malignant transformation of premalignant MGUS into multiple myeloma.

April 1, 2007Cancer CellOpen Access

The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis

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Authors

DCDaniel R. CarrascoBrigham and Women's Hospital DCDaniel R. CarrascoBrigham and Women's Hospital KSKumar SukhdeoBrigham and Women's Hospital

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Implication

Transgenic animal study reveals that sustained XBP-1s expression causes multiple myeloma features in mice, indicating a direct pathogenic driver of plasma cell malignancy.

Key Points

To determine whether dysregulated expression of the spliced transcription factor XBP-1 drives the malignant transformation of premalignant MGUS into multiple myeloma.
Engineered transgenic mice with Emu-directed expression of the spliced isoform of XBP-1 (XBP-1s) targeted to plasma-cell development pathways.
Tracked age-dependent pathology, serum immunoglobulin levels, bone lesions, and transcriptional profiles in lymphoid and multiple myeloma cells.
Transgenic mice overexpressing XBP-1s developed phenotypes mimicking human MGUS that progressed with age to multiple myeloma, featuring high serum immunoglobulin, subendothelial deposits, and lytic bone lesions.
Transcriptional profiling of murine myeloma cells demonstrated aberrant expression patterns matching genes known to be dysregulated in human multiple myeloma.

Cite This Study

Carrasco et al. (2007) studied this question.

synapsesocial.com/papers/6a01ed094e84148937d8b4af https://doi.org/10.1016/j.ccr.2007.02.015

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Implication

Transgenic animal study reveals that sustained XBP-1s expression causes multiple myeloma features in mice, indicating a direct pathogenic driver of plasma cell malignancy.

The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis

Discussion

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Implication

Key Points

Cite This Study

The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis

Discussion

Member takes

Implication

Key Points

Cite This Study

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