Automated Assessment of Brain CT After Cardiac Arrest—An Observational Derivation/Validation Cohort Study

Martin Kenda; Michael Scheel; André Kemmling; Noelle Aalberts; Christopher Guettler; Kaspar Josche Streitberger; Christian Storm; Christoph J. Ploner; Christoph Leithner

doi:10.1097/ccm.0000000000005198

July 16, 2021Critical Care Medicine

Automated Assessment of Brain CT After Cardiac Arrest—An Observational Derivation/Validation Cohort Study

View Full Paper

Ask AI

Bookmark

Share

Key Points

To determine whether automated quantification of the gray-white-matter ratio on brain CT scans can accurately predict poor neurological outcome in patients resuscitated from cardiac arrest.
Conducted an observational derivation (n = 309) and validation (n = 207) cohort study evaluating 516 CT scans from 433 cardiac arrest patients within 10 days of arrest at a single academic medical center.
Employed automated CT image decomposition through brain atlas coregistration to determine gray-white-matter ratios, defining poor outcome as Cerebral Performance Category 4–5 (coma, unresponsive wakefulness, or death) at discharge.
Automated gray-white-matter ratio at the basal ganglia level yielded an area under the curve of 0.86 (95% CI, 0.80–0.93) for CT scans obtained more than 24 hours after cardiac arrest, with consistent performance in the validation cohort.
At a gray-white-matter ratio threshold below 1.10 on scans taken after 24 hours, poor outcome was predicted with 100% specificity (95% CI, 87%–100% derivation; 88%–100% validation) and sensitivities of 49% (95% CI, 36%–58% derivation) and 38% (95% CI, 27%–50% validation).

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Observational cohort study shows automated brain CT gray-white-matter ratio accurately predicts poor outcome after cardiac arrest, suggesting a reliable tool for standardized neurological prognosis.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Kenda et al. (2021) studied this question.

synapsesocial.com/papers/6a01ed2b950a93c470d8c04e https://doi.org/10.1097/ccm.0000000000005198

View Full Paper

Ask AI

Bookmark

Share

Automated Assessment of Brain CT After Cardiac Arrest—An Observational Derivation/Validation Cohort Study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Automated Assessment of Brain CT After Cardiac Arrest—An Observational Derivation/Validation Cohort Study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

Keep reading