Why the study?
Does ranolazine improve diastolic dysfunction in a DOCA-salt hypertensive mouse model?
Does ranolazine improve diastolic dysfunction in a DOCA-salt hypertensive mouse model?
Ranolazine reverses diastolic dysfunction in a hypertensive mouse model, likely through direct modulation of myofilament calcium sensitivity rather than late sodium current.
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Ranolazine effects in hypertensive mice should not change practice; leaves open translation to human diastolic dysfunction therapy.
Lovelock et al. (2012) studied this question.
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