Why the study?
Preeclampsia is associated with increased long-term cardiovascular risk, but the underlying functional and structural mechanisms remain unknown.
Does pravastatin reduce cardiovascular alterations in a rat model of preeclampsia?
Does pravastatin reduce cardiovascular alterations in a rat model of preeclampsia?
Pravastatin may reverse structural changes of cardiac hypertrophy and fibrosis induced by preeclamptic pregnancy, potentially reducing long-term cardiovascular risk.
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Pravastatin may ameliorate postpartum cardiac remodeling in rat preeclampsia models; hypothesis-generating, requires human trials before any clinical consideration.
Kräker et al. (2019) studied this question.
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