In vitro experimental study demonstrates the structural stability of dual-labeled chitosan-hyaluronic acid nanogels, indicating their viability as nanoscale delivery systems.
) varying from 0.3% to 47% were determined, according to the grafted synthon. Nanohydrogels were then obtained by ionic gelation between functionalized hyaluronic acids and chitosan (CS) and tripolyphosphate (TPP) as a cross-linker. Nanohydrogels for which HA and CS were respectively labeled by rhodamine and fluorescein which are a fluorescent donor-acceptor pair were subjected to FRET experiments to evaluate the stability of these nano-assemblies.
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Malytskyi et al. (2022) studied this question.
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