Activation of the renal renin-angiotensin system in diabetes--new concepts
Population
Diabetic models, including mice lacking tubuloglomerular feedback (TGF)
Design
Review
Authors
Discussion
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Implication
Challenges tubular hypothesis of diabetic hyperfiltration; hypothesis-generating and should not yet change practice.
Structured PICO
P
Population
Diabetic models, including mice lacking tubuloglomerular feedback (TGF)
Evidence from mice lacking tubuloglomerular feedback challenges the prevailing 'tubular hypothesis' by showing that TGF is not the primary cause of diabetes-induced glomerular hyperfiltration.
Cite This Study
Peti‐Peterdi et al. (2008) studied this question.