The Collecting Duct Is the Major Source of Prorenin in Diabetes
Population
Diabetic Munich-Wistar rats and a collecting duct cell line (M1)
Comparison
Angiotensin II type 1 receptor blockade with… vs Non-diabetic controls; untreated cells
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Does not support changing diabetes-related hypertension management; leaves open collecting duct prorenin as a human therapeutic target.
Structured PICO
P
Population
Diabetic Munich-Wistar rats and a collecting duct cell line (M1)
I
Intervention
Angiotensin II type 1 receptor blockade with Olmesartan (in vivo); Angiotensin II treatment (in vitro)
C
Comparator
Non-diabetic controls (in vivo); untreated cells (in vitro)
O
Outcome
Renin granular content in the collecting duct and juxtaglomerular apparatus, and prorenin enzymatic activitysurrogate
In a rat model of diabetes, the collecting duct is a major source of prorenin, which is stimulated by diabetes and Angiotensin II, challenging the paradigm that the juxtaglomerular apparatus is the primary source.
Cite This Study
Kang et al. (2008) studied this question.