Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 18, 1997Proceedings of the National Academy of SciencesOpen Access

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

View Full Paper
Ask AI
Bookmark
Share

Authors

MMMila E. McCurrachNYU Langone HealthTCThomas M. ConnorOxford University Hospitals NHS TrustCKC. Michael KnudsonUniversity of Iowa

Discussion

Loading...

Member takes

Implication

Key Points

Key points are not available for this paper at this time.

Cite This Study

McCurrach et al. (1997) studied this question.

synapsesocial.com/papers/6a024f2032000ff7cc75ffe2https://doi.org/10.1073/pnas.94.6.2345
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression1993 · 366 citations
  2. 2Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.1993 · 671 citations
  3. 3p53 Status and the Efficacy of Cancer Therapy in Vivo1994 · 1,482 citations
  4. 4The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein.1996 · 352 citations
  5. 5Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.1994 · 290 citations