What question did this study set out to answer?

To outline the physiological mechanisms of phosphorus homeostasis, review clinical strategies for managing hyperphosphatemia in chronic kidney disease, and identify causes of treatment failure.

January 12, 2015Saudi Pharmaceutical JournalOpen Access

Hyperphosphatemia Management in Patients with Chronic Kidney Disease

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Authors

ASAhmed M. ShamanKing Saud University SKS. KowalskiBioClinica (United States)

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Implication

Review highlights treatment strategies and physiological drivers of hyperphosphatemia in chronic kidney disease, indicating gastric pH significantly alters phosphate binder efficiency.

Key Points

To outline the physiological mechanisms of phosphorus homeostasis, review clinical strategies for managing hyperphosphatemia in chronic kidney disease, and identify causes of treatment failure.
Narrative review synthesizing current literature on phosphorus homeostasis and hyperphosphatemia management in chronic kidney disease.
Evaluation of pharmacological and nonpharmacological approaches, with specific analysis of gastrointestinal variables such as gastric pH on phosphate binder activity.
Hyperphosphatemia drives cardiovascular calcification, renal osteodystrophy, and secondary hyperparathyroidism, increasing cardiovascular morbidity and overall mortality.
Alterations in gastric pH can substantially reduce phosphate binder binding capacity, representing a key contributor to clinical failure in controlling serum phosphorus.

Cite This Study

Shaman et al. (2015) studied this question.

synapsesocial.com/papers/6a0255a3cd2189d558f601cd https://doi.org/10.1016/j.jsps.2015.01.009

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Implication

Review highlights treatment strategies and physiological drivers of hyperphosphatemia in chronic kidney disease, indicating gastric pH significantly alters phosphate binder efficiency.

Hyperphosphatemia Management in Patients with Chronic Kidney Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Hyperphosphatemia Management in Patients with Chronic Kidney Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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