Key result
STEMI incidence in adults aged 18-40 rises by ~1.6 per 100,000 person-years alongside increasing mortality.
Why the study?
While overall STEMI incidence and mortality have declined, younger adults aged 18 to 40 years have experienced a different trend, prompting an evaluation of STEMI incidence, mortality, and mechanical circulatory support utilization in this population.
Cohort (n=34,888,311)
Yes
STEMI incidence, mortality, and mechanical circulatory support utilization have significantly increased among young adults aged 18-40 years from 2004 to 2023.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to rising STEMI burden in young adults; leaves open drivers and prevention targets.
AIM While the overall incidence and mortality of ST-elevation myocardial infarction (STEMI) have declined, younger adults 18-40 years of age have experienced a different trend. We examined STEMI incidence, mortality, and mechanical circulatory support (MCS) utilization in young patients from 2004 to 2023 using the TriNetX Research Network database. METHODS We conducted an analysis of a cohort of 34,888, 311 patients aged 18-40 years between January 1, 2004, and December 31, 2023, using TriNetX Research Network database. Linear regression analysis was used to calculate the incidence rate of STEMI. The incidence of major cardiovascular risk factors including diabetes mellitus, hypertension, nicotine dependence, obesity, cocaine use disorder, and stimulant use disorder, were evaluated in the same cohort over the same period. Mortality and MCS utilization were examined from 2010 onward. RESULTS STEMI incidence rate increased significantly from 2004 to 2023 (1.59/100,000 cases/person-year; p < 0.0001). Mortality incidence rate increased annually by 108/100,000 (p < 0.0001), while MCS utilization rose by 38.8/100,000 (p < 0.0001). Cardiovascular risk factors also increased significantly. CONCLUSION STEMI incidence, mortality, and MCS utilization among young adults have increased between 2004 and 2023, with a steeper uptrend observed post-COVID. Further research is needed to identify effective prevention and treatment strategies for STEMI in young adults, particularly in the post-COVID era.
No takes yet. Share an insight, caveat, or question.
Khalil et al. (2026) conducted a cohort in ST-elevation myocardial infarction (STEMI) (n=34,888,311). STEMI incidence among adults aged 18-40 increased from 2004 to 2023 by 1.59/100,000 cases/person-year (p<0.0001), alongside rising mortality (108/100,000) and MCS utilization (38.8/100,000).
Synapse has enriched 10 related papers. Consider them for comparative context: