Central Aortic Pressure Indices in Young Women With Excessive Body Weight and Arterial Hypertension

Q: What are the key findings of this study?

Young women with stage 1 arterial hypertension and excess body weight had significantly higher central systolic aortic pressure (130.8 vs 120.3 mmHg) compared to those with normal body weight.

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Arterial hypertension and excess body weight (n=63). Intervention: Excess body weight (BMI ≥ 25 kg/m²) vs. Normal body weight. Primary outcome: Central systolic aortic pressure (cSBP) (p=<0.05).

Q: What question did this study set out to answer?

To investigate changes in central aortic pressure, central hemodynamics, tumor necrosis factor-α, and C-reactive protein in young women with arterial hypertension and excess body weight.

O. M. Bilovol; I. I. Kniazkova; V. O. Golovachova; V. O. Barbashova; N. V. Kuzminova; L. О. Sosonna; M. V. Bogun

doi:10.26724/2079-8334-2025-4-94-31-35

January 1, 2025World of Medicine and BiologyOpen Access

Central Aortic Pressure Indices in Young Women With Excessive Body Weight and Arterial Hypertension

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Key result

Excess weight in young women with stage 1 hypertension links to ~11 mmHg higher cSBP.

P<0.05
n=63

Why the study?

The study aimed to examine central aortic pressure, central hemodynamics, TNF-alpha, and C-reactive protein in young women with arterial hypertension and excessive body weight.

Does excess body weight worsen central aortic pressure indices, arterial stiffness, and inflammatory markers in young women with stage 1 arterial hypertension?

Key Points

To investigate changes in central aortic pressure, central hemodynamics, tumor necrosis factor-α, and C-reactive protein in young women with arterial hypertension and excess body weight.
Included 43 women aged 18–40 years (mean age 36.7±2.3 years) with persistent stage 1 arterial hypertension, divided into a normal weight group (N=20; BMI 24.3±0.5 kg/m²) and an excess body weight group (N=23; BMI 28.9±0.6 kg/m²).
Enrolled a healthy control group of 20 women (mean age 36.5±2.7 years; BMI 24.1±0.5 kg/m²) with normal blood pressure and body weight.
Assessed central hemodynamic parameters, pulse wave velocity, and serum concentrations of tumor necrosis factor-α and C-reactive protein.
Young women with stage 1 arterial hypertension demonstrated significantly greater increases in vascular stiffness and central aortic pressure compared with healthy controls.
Hypertensive women with excess body weight exhibited significantly higher systolic, diastolic, mean, and pulse aortic pressures, as well as pulse wave velocity, compared to hypertensive women with normal body weight.
Serum concentrations of tumor necrosis factor-α and C-reactive protein were elevated in patients with stage 1 hypertension, with more pronounced increases observed in those with excess body weight.

Study Design

Type

Cross-Sectional (n=63)

Multicenter

No

Structured PICO

Does excess body weight worsen central aortic pressure indices, arterial stiffness, and inflammatory markers in young women with stage 1 arterial hypertension?

P

Population

63 young women aged 18-40, including 43 with persistent stage 1 arterial hypertension (mean age 36.7±2.3 years; 20 with normal body weight and 23 with excess body weight) and 20 healthy controls with normal blood pressure and body weight (mean age 36.5±2.7 years).

I

Intervention

Excess body weight (BMI ≥ 25 kg/m²) in the context of stage 1 arterial hypertension

C

Comparator

Normal body weight (BMI < 25 kg/m²) in the context of stage 1 arterial hypertension, and healthy normotensive controls

O

Outcome

Central aortic pressure parameters (systolic, diastolic, and pulse aortic pressure), pulse wave velocity (PWV), and serum concentrations of tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP)surrogate

Main Result

Absolute Event Rate: 130.8% vs 120.3%

p-value: p=<0.05

Excess body weight in young women with stage 1 arterial hypertension is associated with increased arterial stiffness, central aortic pressure, and systemic inflammation compared to normal-weight hypertensive peers.

Limitations

Small sample size
Need for additional large-scale studies
Lack of analysis of other cardiovascular risk factors such as physical activity and smoking
Lack of analysis of the influence of other cardiovascular risk factors, such as physical activity and smoking

Implication

Excess body weight was associated with higher central aortic pressure in young women with stage 1 hypertension; hypothesis-generating, prospective studies needed before practice implications.

Abstract

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Discussion

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Cite This Study

Bilovol et al. (2025) conducted a cross-sectional in Arterial hypertension and excess body weight (n=63). Excess body weight (BMI ≥ 25 kg/m²) vs. Normal body weight was evaluated on Central systolic aortic pressure (cSBP) (p=<0.05). Young women with stage 1 arterial hypertension and excess body weight had significantly higher central systolic aortic pressure (130.8 vs 120.3 mmHg) compared to those with normal body weight.

synapsesocial.com/papers/6a02596745880192ae4240ef https://doi.org/10.26724/2079-8334-2025-4-94-31-35

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Central Aortic Pressure Indices in Young Women With Excessive Body Weight and Arterial Hypertension

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Central Aortic Pressure Indices in Young Women With Excessive Body Weight and Arterial Hypertension

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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