Key result
Obstructive coronary lesions in NSTEMI are linked to a ~43% lower likelihood of ST-segment normalization.
Why the study?
The study was conducted to assess the characteristics and dynamics of ST-segment and T-wave changes in non-ST-segment elevation myocardial infarction.
Does the presence of obstructive coronary artery lesions affect the electrocardiographic dynamics of the ST segment and T wave in patients with NSTEMI?
Observational (n=200)
No
Does the presence of obstructive coronary artery lesions affect the electrocardiographic dynamics of the ST segment and T wave in patients with NSTEMI?
Absolute Event Rate: 40.6% vs 71.3%
p-value: p=<0.001
In NSTEMI patients, obstructive coronary artery disease is associated with deeper, more persistent ST-segment depression and a higher risk of in-hospital progression to transmural myocardial infarction compared to non-obstructive disease.
Obstructive lesions link to persistent ST changes in NSTEMI; leaves open whether ECG dynamics aid risk stratification.
To assess the characteristics and dynamics of ST-segment and T-wave changes in non–ST-segment elevation myocardial infarction, 200 patients were examined, including 164 men and 36 women; the mean age was 62.21±9.38 years. Based on coronary angiography findings, patients were divided into two groups: Group I included 94 patients with non–ST-segment elevation myocardial infarction and non-obstructive coronary artery lesions (stenosis <50 %); Group II included 106 patients with non–ST-segment elevation myocardial infarction and obstructive coronary artery lesions (stenosis≥50 %). In Group I, predominantly transient electrocardiographic changes were observed. During the acute phase, ST-segment depression in leads V4–V6 was most common (62.8 % of patients), and less frequent in leads II, III, and aVF (21.3 %). In Group II, ST-segment depression was deeper and more persistent; ST depression≥1 mm was recorded in 79.2 % of patients, predominantly in leads V4–V6 and II, III, aVF, which was significantly more frequent than in Group I (p=0.016). No significant intergroup differences were found for isolated T-wave inversion or for the combined ST↓+T pattern. ST-segment normalization on days 5–7 occurred significantly more often in Group I (p<0.001). Progression to transmural myocardial infarction (ST-segment elevation myocardial infarction) was observed only in Group II (p=0.019).
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Sh. Khalilov (2025) conducted an observational in Non-ST-segment elevation myocardial infarction (n=200). Obstructive coronary artery lesions (stenosis ≥50%) vs. Non-obstructive coronary artery lesions (stenosis <50%) was evaluated on ST-segment normalization on days 5-7 (p=<0.001). Obstructive coronary lesions in NSTEMI patients were associated with significantly lower rates of ST-segment normalization on days 5-7 (40.6% vs 71.3%) compared to non-obstructive lesions.
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