Why the study?
How does renal insufficiency and hemodialysis affect fasting serum gastrointestinal hormone concentrations?
Observational
How does renal insufficiency and hemodialysis affect fasting serum gastrointestinal hormone concentrations?
Renal insufficiency is associated with significantly elevated levels of gastrointestinal hormones, which are largely unaffected by hemodialysis except for gastric inhibitory polypeptide.
Answers are grounded in this paper and cite their sources.
Elevated GI hormones in severe renal failure may confound assay interpretation; leaves open clinical relevance and dialysis effects.
Fasting serum gastrin, cholecystokinin, glucagon, and gastric inhibitory polypeptide concentrations were simultaneously measured in normal subjects and in patients with different degrees of renal failure. Values of gastrin, cholecystokinin, gastric inhibitory polypeptide, and glucagon were significantly higher in all patients with serum creatinine concentrations greater than 3 mg/dl than in controls (P less than 0.01). The degree of renal insufficiency was significantly correlated (P less than 0.05) with serum concentrations of each hormone, but no significant linear correlation existed among the serum concentrations of different gastrointestinal hormones in individuals. Hemodialysis did not significantly alter predialysis serum gastrin, cholecystokinin, or glucagon concentration, but the serum gastric inhibitory polypeptide concentration decreased by 30% (P less than 0.01) after hemodialysis. The disproportionate increases of hormones with antagonistic actions may alter gastrointestinal function in renal insufficiency.
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Owyang et al. (1979) conducted an observational in Renal Insufficiency. Renal failure vs. Normal subjects was evaluated on Fasting serum gastrin, cholecystokinin, glucagon, and gastric inhibitory polypeptide concentrations (p=<0.01).
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