Transcatheter aortic valve replacement was associated with reduced odds of in-hospital mortality (adjusted OR 0.22; 95% CI 0.10-0.46) compared with surgical replacement in patients with prior CABG.
Observational (n=566,705)
Yes
Does transcatheter aortic valve replacement reduce mortality and complications compared to surgical aortic valve replacement in patients with prior coronary artery bypass graft surgery?
In patients with prior CABG, TAVR is associated with significantly lower in-hospital mortality, fewer complications, shorter length of stay, and reduced costs compared to SAVR.
Effect estimate: adjusted OR 0.22 (95% CI 0.10-0.46)
BACKGROUND With the aging US population and improvements in diagnostics, the prevalence of aortic stenosis is rising, including among patients with prior coronary artery bypass graft surgery. This study examined acute outcomes of transcatheter aortic valve replacement versus surgical aortic valve replacement in a national cohort of patients with prior coronary artery bypass graft surgery. METHODS Using the 2016-2021 Nationwide Readmissions Database, we identified adult patients (≥18 years old) with prior coronary artery bypass graft surgery undergoing transcatheter or surgical aortic valve replacement. Patients with concomitant cardiac procedures were excluded. Outcomes included in-hospital mortality, postoperative complications, hospitalization costs, length of stay, and 30-day nonelective readmissions. Multivariable regression models were employed to evaluate associations. RESULTS Among an estimated 566, 705 patients, 3. 0% of surgical aortic valve replacement recipients and 10. 4% of transcatheter aortic valve replacement recipients had prior coronary artery bypass graft surgery. Use of surgical aortic valve replacement declined from 1, 347 cases in 2016 to 593 cases in 2021, whereas transcatheter procedures increased from 8, 464 to 10, 821 cases (both Cuzick's test for trends <. 001). After multivariable adjustment and surgical aortic valve replacement as reference, transcatheter aortic valve replacement was associated with reduced odds of in-hospital mortality (adjusted odds ratio 0. 22, 95% confidence interval 0. 10-0. 46) and intraoperative (adjusted odds ratio 0. 46, 95% confidence interval 0. 24-0. 89), respiratory (adjusted odds ratio 0. 37, 95% confidence interval 0. 26-0. 53), and renal (adjusted odds ratio 0. 50, 95% confidence interval 0. 33-0. 75) complications, along with shorter hospital length of stay (-2. 7 days, 95% confidence interval -3. 1 to -2. 2 days) and lower costs (-32, 000, 95% confidence interval -62, 000 to -180). No significant differences in 30-day readmissions were noted (adjusted odds ratio 0. 68, 95% confidence interval 0. 42-1. 10). CONCLUSION Transcatheter aortic valve replacement offers lower mortality, fewer complications, and reduced costs compared with surgical aortic valve replacement, supporting its role as a favorable treatment for aortic stenosis in patients with prior coronary artery bypass graft surgery.
Ng et al. (Tue,) conducted a observational in Aortic stenosis with prior coronary artery bypass graft surgery (n=566,705). Transcatheter aortic valve replacement vs. Surgical aortic valve replacement was evaluated on In-hospital mortality (adjusted OR 0.22, 95% CI 0.10-0.46). Transcatheter aortic valve replacement was associated with reduced odds of in-hospital mortality (adjusted OR 0.22; 95% CI 0.10-0.46) compared with surgical replacement in patients with prior CABG.