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November 1, 1994Journal of Cell Science

Differential localization of myosin-II isozymes in human cultured cells and blood cells

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Population

Human cultured cells and blood cells

Design

Preclinical

Authors

PMPamela MaupinCPCarrie L. PhillipsRARobert Adelstein

Discussion

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Overview

Suggests shared contractile roles at the furrow; leaves open isoform contributions to cytokinesis in mammalian systems.

Structured PICO

P
Population
Human cultured cells (HeLa cells, melanoma cells) and blood cells (platelets, lymphocytes, neutrophils, monocytes, eosinophils)
I
Intervention
Fluorescently labeled purified polyclonal antibodies to human cytoplasmic myosin-IIA and myosin-IIB
O
Outcome
Subcellular localization of myosin-II isozymes

Myosin-IIA and myosin-IIB have distinct subcellular localizations in interphase cells but co-localize at the cleavage furrow during cell division.

Cite This Study

Maupin et al. (1994) studied this question.

synapsesocial.com/papers/6a025a61a845aea65311a7b0https://doi.org/10.1242/jcs.107.11.3077
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