Higher pericoronary fat attenuation index (FAI) values provided incremental prognostic value for major adverse cardiovascular events (HR 3.28; 95% CI 2.03 to 5.32; P<0.001).
Meta-Analysis
Does higher pericoronary fat attenuation index (FAI) predict major adverse cardiovascular events (MACEs) and differentiate vulnerable from stable plaques in patients with coronary heart disease?
Higher pericoronary fat attenuation index (FAI) is significantly associated with an increased risk of MACE and serves as a promising imaging biomarker for detecting coronary inflammation and vulnerable plaques.
Effect estimate: HR 3.28 (95% CI 2.03 to 5.32)
p-value: p=<0.001
AIM: The aim of this comprehensive updated systematic review and meta-analysis was to evaluate the prognostic value of the pericoronary fat attenuation index (FAI) for major adverse cardiovascular events (MACEs) and its ability to differentiate vulnerable from stable plaques. MATERIALS AND METHODS: A comprehensive literature search was conducted in PubMed, the Cochrane library, and Embase with the search terms 'Epicardial Adipose Tissue' and 'Tomography, X-Ray Computed' until 28 May 2025. Data were extracted and methodological quality was assessed by two independent investigators according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Fifteen studies were included in this systematic review and meta-analysis. All statistical analyses were performed using Review Manager software, version 5.3 and R 4.5.2. RESULTS: The results indicated that higher pericoronary FAI values provided incremental prognostic value for MACE in studies with prospective follow-up (hazard ratio HR=3.28, 95% confidence interval CI: 2.03 to 5.32, P<0.001, I CONCLUSION: These collective findings underscore the role of pericoronary FAI as a promising indicator for detecting coronary inflammation, distinguishing vulnerable plaques, and predicting MACE.
Long et al. (Fri,) conducted a meta-analysis in Coronary heart disease. Pericoronary fat attenuation index (FAI) was evaluated on Major adverse cardiovascular events (MACEs) (HR 3.28, 95% CI 2.03 to 5.32, p=<0.001). Higher pericoronary fat attenuation index (FAI) values provided incremental prognostic value for major adverse cardiovascular events (HR 3.28; 95% CI 2.03 to 5.32; P<0.001).