Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 30, 2026Herz

Advanced interatrial block predicts ~6-fold greater risk of appropriate ICD shocks in HCM.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

The prognostic impact of advanced interatrial block on appropriate and inappropriate ICD shocks in patients with hypertrophic cardiomyopathy remained unclear.

Does advanced interatrial block predict appropriate and inappropriate ICD shocks in patients with hypertrophic cardiomyopathy?

Population

184 consecutive patients with HCM who underwent ICD implantation

Comparison

Advanced IAB vs absence of advanced IAB

Design

Retrospective cohort study

Follow-up

Median 68.5 months

Key result

Advanced interatrial block independently predicted appropriate (HR 6.03; 95% CI 2.68-13.57; p<0.001) and inappropriate ICD shocks (HR 3.50; 95% CI 1.78-6.86; p<0.001) in patients with HCM.

Authors

NYNizamettin Selçuk YelgeçCACan Baba ArınAAAyşegül Aygün

Discussion

Loading...

Member takes

Overview

Advanced IAB may flag higher-risk ICD patients; hypothesis-generating and requires prospective validation before guiding therapy.

Key Points

  • This research aims to investigate the prognostic impact of advanced interatrial block on ICD shocks in hypertrophic cardiomyopathy patients.
  • Retrospective analysis of patients with hypertrophic cardiomyopathy undergoing ICD implantation from 2014 to 2024.
  • Defined advanced interatrial block as P-wave duration of ≥ 120 ms with biphasic morphology.
  • Utilized Kaplan-Meier analysis and multivariable Cox proportional hazards regression to assess time to first ICD shock.
  • Patients with advanced interatrial block had lower shock-free survival for appropriate and inappropriate ICD shocks.
  • Advanced interatrial block predicted appropriate ICD shocks (HR: 6.03, 95% CI: 2.68-13.57; p < 0.001).
  • Advanced interatrial block was an independent predictor of inappropriate ICD shocks (HR: 3.50, 95% CI: 1.78-6.86; p < 0.001).

Study Design

Type

Cohort (n=184)

Structured PICO

Does advanced interatrial block predict appropriate and inappropriate ICD shocks in patients with hypertrophic cardiomyopathy?

P
Population
184 consecutive patients with hypertrophic cardiomyopathy (HCM) who underwent ICD implantation between 2014 and 2024
I
Intervention
Presence of advanced interatrial block (IAB), defined as a P-wave duration of ≥ 120 ms with biphasic morphology in the inferior leads
C
Comparator
Absence of advanced interatrial block
O
Outcome
Time to first ICD shock (appropriate for sustained ventricular tachycardia/ventricular fibrillation, or inappropriate for supraventricular arrhythmias/device-related causes)hard clinical

Main Result

Effect estimate: HR 6.03 (95% CI 2.68-13.57)

p-value: p=<0.001

Advanced interatrial block on a standard ECG is a strong independent predictor of both appropriate and inappropriate ICD shocks in patients with hypertrophic cardiomyopathy, offering a simple tool for risk stratification.

Cite This Study

Yelgeç et al. (2026) conducted a cohort in Hypertrophic cardiomyopathy (n=184). Advanced interatrial block was evaluated on Appropriate ICD shocks (HR 6.03, 95% CI 2.68-13.57, p=<0.001). Advanced interatrial block independently predicted appropriate (HR 6.03; 95% CI 2.68-13.57; p<0.001) and inappropriate ICD shocks (HR 3.50; 95% CI 1.78-6.86; p<0.001) in patients with HCM.

synapsesocial.com/papers/6a025dcf93868c48f309362fhttps://doi.org/10.1007/s00059-026-05378-6
View Full Paper
Ask AI
Bookmark
Share