Characterization and anatomical distribution of AF driver sources identified by the novel Ockham AF mapping module

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Atrial fibrillation (n=110). Intervention: Ockham AF Mapping module. Primary outcome: Identification and characteristics of AF drivers.

Tetsuma Kawaji; Yosuke Murase; Soichiro Yamashita; Saki Yamano; Ryuta Ishida; Misaki Naka; Bingyuan Bao; Tomoya Kimura; Shun Hojo; Shintaro Matsuda; Masashi Kato; Takafumi Yokomatsu; Shinji Miki

doi:10.1016/j.ijcard.2026.134505

April 17, 2026International Journal of Cardiology

Characterization and anatomical distribution of AF driver sources identified by the novel Ockham AF mapping module

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Key result

Ockham AF Mapping module reliably identifies AF drivers with short local CL and high duty cycle.

n=110

Why the study?

The study aimed to validate the characteristics of AF drivers identified by the novel Ockham AF Mapping module.

Does the Ockham AF Mapping module reliably identify AF drivers in patients with AF undergoing ablation?

Key Points

This study aims to validate the characteristics of atrial fibrillation drivers identified by the Ockham AF Mapping module.
Retrospective multicenter analysis of 110 patients with atrial fibrillation undergoing ablation.
AF drivers defined by a local cycle length (CL) ≤ median and a duty cycle ≥80%.
A total of 112,388 beats were analyzed to identify highlighted driver areas.
Identified 517 driver areas across 226 atria based on characteristics of short local CL and high duty cycle.
Median area for analysis was 11.9 cm (range 3.6-19.0 cm); inconsistent AF activation hindered complete analysis.
The Ockham module reliably characterizes AF drivers in a multicenter setting.

Study Design

Type

Observational (n=110)

Multicenter

Yes

Structured PICO

Does the Ockham AF Mapping module reliably identify AF drivers in patients with AF undergoing ablation?

P

Population

110 consecutive patients with atrial fibrillation (AF) who underwent ablation

I

Intervention

Ockham AF Mapping module

O

Outcome

Identification and characterization of AF drivers (defined by short Local CL and high Duty Cycle)surrogate

The Ockham AF Mapping module is a reliable tool for identifying AF drivers based on short local cycle length and high duty cycle during ablation.

Limitations

Due to inconsistent AF activation, the module could not analyze a median area of 11.9(3.6-19.0) cm

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Implication

Supports multicenter feasibility of Ockham AF mapping; leaves open prospective validation before clinical adoption.

Abstract

AIMS: The Ockham AF Mapping module is a novel mapping system that identifies atrial fibrillation(AF) drivers based on short cycle lengths and localized continuous activation. This study aimed to validate the characteristics of AF drivers identified by the novel module. METHODS AND RESULTS: This retrospective multicenter study enrolled 110 consecutive patients with AF who underwent ablation using the Ockham module. AF drivers were defined by a short Local Cycle Length (CL) ≤ the median of the minimum and peak CL, and a high Duty Cycle (the ratio of the electrical activation time to the Local CL) of ≥80%. A total of 112,388 beats were analyzed, identifying 517 highlighted driver areas in 226 atria. CONCLUSIONS: The Ockham AF Mapping module reliably identified AF drivers, characterized by short Local CL and high Duty Cycle.

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Cite This Study

Kawaji et al. (2026) conducted an observational in Atrial fibrillation (n=110). Ockham AF Mapping module was evaluated on Identification and characteristics of AF drivers. The Ockham AF Mapping module reliably identified 517 AF driver areas in 226 atria among 110 patients, characterized by short Local Cycle Length and high Duty Cycle.

synapsesocial.com/papers/6a025df093868c48f3093772 https://doi.org/10.1016/j.ijcard.2026.134505

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Characterization and anatomical distribution of AF driver sources identified by the novel Ockham AF mapping module

Key Points

Study Design

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Characterization and anatomical distribution of AF driver sources identified by the novel Ockham AF mapping module

Key Points

Study Design

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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