Nickel‐Catalyzed Three‐Component [3+2+2] Cocyclization of Ethyl Cyclopropylideneacetate and Alkynes—Selective Synthesis of Multisubstituted Cycloheptadienes

Ménage à trois: Seven-membered carbocycles are formed by the three-component [3+2+2] cycloaddition of ethyl cyclopropylideneacetate and two different alkynes in the presence of a Ni0/PPh3 catalyst (see scheme). In this one-pot reaction, a highly chemo- and regioselective coupling proceeds, and the cycloheptadiene derivatives are isolated as single isomers. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z504050_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.