What question did this study set out to answer?

To critically evaluate recent progress and mechanistic understanding in nickel-catalyzed reductive cyclizations and multicomponent coupling reactions.

June 17, 2004Angewandte Chemie International Edition

Nickel‐Catalyzed Reductive Cyclizations and Couplings

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Authors

JMJohn MontgomeryUniversity of Michigan

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Implication

Narrative review evaluates nickel-catalyzed reductive cyclizations and multicomponent couplings, highlighting efficient pathways to assemble polycyclic systems from simple precursors.

Key Points

To critically evaluate recent progress and mechanistic understanding in nickel-catalyzed reductive cyclizations and multicomponent coupling reactions.
Synthesized literature on multicomponent catalytic processes that couple two or more pi components with main-group or transition-metal reagents.
Assessed mechanistic frameworks, focusing on the timing of bond constructions and the behavior of reactive organonickel intermediates.
Nickel-catalyzed reductive processes enable the direct construction of multiple contiguous stereocenters and complex polycyclic frameworks from simple, achiral precursors.
Multicomponent couplings facilitate diverse carbon-carbon bond formations under mild conditions, streamlining routes to complex organic substructures.

Cite This Study

John Montgomery (2004) studied this question.

synapsesocial.com/papers/69d95ed05e5bcb4e3b835d86 https://doi.org/10.1002/anie.200300634

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Implication

Narrative review evaluates nickel-catalyzed reductive cyclizations and multicomponent couplings, highlighting efficient pathways to assemble polycyclic systems from simple precursors.

Nickel‐Catalyzed Reductive Cyclizations and Couplings

Discussion

Member takes

Implication

Key Points

Cite This Study

Nickel‐Catalyzed Reductive Cyclizations and Couplings

Discussion

Member takes

Implication

Key Points

Cite This Study

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