Genetic determinants of responsiveness to mesenchymal stem cell injections in non-ischemic dilated cardiomyopathy

Figures

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  Fig. 1. Consort diagram including initial randomization of original trial and genetic analysis. Thirty-four patients were included into the genetic analysis and divided into three groups; positive (PV+) or negative (V−) for pathologic variant and uncertain (VUS).

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  Fig. 2. Genotype modify responsiveness in cardiac function and functional capacity. A) V- patients had the greatest increase in EF at 12 months compared with VUS. EF decreased in PV+ patients. B) Six-minute walk distance increased in the V− patients vs. VUS and PV+. C) V− patients improved to a greater extent in MLHFQ contrasted with VUS and PV+. D) Percentage change in NYHA shows significant difference between groups. V− improved by 60% in contrast to 53% in VUS and 25% in PV+. E) EPC-cfu significantly increased over time only in V− group. V− = negative for any pathologic variants group (green), VUS = variants of uncertain significance group (orange), PV+ = positive for pathologic/likely pathologic variant group (red). *p = <0.05, **p = 0.01 ***p = 0.001 ****p<0.0001. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

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  Fig. 3. Genetic variation affect MACE and Survival in response to MSC delivery. A) V− patients had 100% survival, VUS had 85% survival, and PV+ had 40% survival (Log-rank (Mantel-Cox) test p = 0.015). Overall, PV+ patient's had a substantial increase in death, transplant, or LVAD risk by 1 year follow-up. B) MACE events differed between groups; V- patients had 0 events, VUS had 7 events, and PV+ had 6 events in 4 patients (Log-rank (Mantel-Cox) test= 0.021). V- = negative for any pathologic variants group (green), VUS = variants of uncertain significance group (orange) PV+ = positive for pathologic/likely pathologic variant group (red). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)