Why the study?
Is Next-Generation Sequencing feasible and effective for identifying the genetic causes of dilated cardiomyopathy?
Is Next-Generation Sequencing feasible and effective for identifying the genetic causes of dilated cardiomyopathy?
Next-Generation Sequencing is a feasible and high-quality tool for clinical genetic diagnostics in patients with dilated cardiomyopathy.
Supports NGS feasibility in DCM diagnostics; leaves open prospective validation before routine clinical adoption.
This is to our knowledge, the first study that comprehensively investigated the genetics of DCM in a large-scale cohort and across a broad gene panel of the known DCM genes. Our results underline the high analytical quality and feasibility of Next-Generation Sequencing in clinical genetic diagnostics and provide a sound database of the genetic causes of DCM.
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Haas et al. (2014) studied this question.
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