Key result
A systematic literature search identified 110 nuclear protein-coding genes and 24 mitochondrial DNA genes implicated in dilated cardiomyopathy, revealing many more genes than currently screened.
Population
Genes implicated in syndromic and non-syndromic dilated cardiomyopathy and peripartum cardiomyopathy
Design
Systematic_review
Authors
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May warrant expanded genetic panels in dilated cardiomyopathy; extends the known gene set but requires validation in larger cohorts.
Systematic Review
A comprehensive systematic review identified 134 genes associated with dilated cardiomyopathy, highlighting the potential to expand current diagnostic genetic panels and the need to validate rare mutations in larger cohorts.
Harakaľová et al. (2015) conducted a systematic review in Dilated cardiomyopathy (DCM). Genetic cataloguing of DCM-associated genes was evaluated on Genes implicated in syndromic and non-syndromic DCM and PPCM. A systematic literature search identified 110 nuclear protein-coding genes and 24 mitochondrial DNA genes implicated in dilated cardiomyopathy, revealing many more genes than currently screened.
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