Key result
Causative genetic mutations in more than 40 genes have been identified in the pathogenesis of dilated cardiomyopathy, affecting diverse cellular structures and pathways.
This review summarizes the major genes and pathophysiologic mechanisms underlying dilated cardiomyopathy.
Broadens genetic heterogeneity in dilated cardiomyopathy; leaves open mutation-specific therapies pending prospective validation.
Cardiomyopathies represent a wide and heterogeneous group of diseases wherein a genetic cause has been consistently identified.Dilated cardiomyopathy (DCM) is characterized by ventricular dilation and progressive systolic dysfunction, and it is the most common form of cardiomyopathy.Causative genetic mutations have been identified in more than 40 genes encoding proteins belonging to different cellular structures and pathways.A great diversity of pathways has been implied in the pathogenesis of DCM, depending on the affected genes and on the dislodged intracellular structures or mechanisms.This review describes the major genes and focus on the pathophysiologic mechanisms of DCM, with a special consideration of the most recent discoveries in the field.
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Araco et al. (2016) conducted a review in Dilated cardiomyopathy. Genetic mutations was evaluated. Causative genetic mutations in more than 40 genes have been identified in the pathogenesis of dilated cardiomyopathy, affecting diverse cellular structures and pathways.
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