Key result
AGE-RAGE pathway links obesity to cardiovascular disease, highlighting circulating AGE and sRAGE as potential biomarkers.
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The AGE-RAGE system is highlighted as a key pro-inflammatory pathway linking obesity to cardiovascular disease, with potential as both a biomarker and therapeutic target.
The AGE (advanced glycation end-products)-RAGE (receptor for AGE) system is a pro-inflammatory pathway that contributes to the pathogenesis of obesity and obesity-related cardiovascular disorders (CVD). Circulating AGE and the soluble form of RAGE (sRAGE) has been suggested as a potential biomarker of CVD related to obesity. In this study, we aim to (1) summarize the current knowledge about the role of obesity in the onset and progression of CVD, (2) discuss the role of the AGE-RAGE system as a pathway promoting obesity and linking obesity to CVD, and (3) highlight available strategies for reducing AGE-RAGE system activation and the associated beneficial effects.
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Vianello et al. (2025) conducted a review in Obesity and cardiovascular diseases. AGE-RAGE system was evaluated. The AGE-RAGE system acts as a pro-inflammatory pathway linking obesity to cardiovascular diseases, with circulating AGE and sRAGE serving as potential biomarkers.
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