Why the study?
Does pioglitazone treatment induce left ventricular dysfunction (measured by ANP and BNP levels) in type 2 diabetes patients without heart failure?
Does pioglitazone treatment induce left ventricular dysfunction (measured by ANP and BNP levels) in type 2 diabetes patients without heart failure?
Baseline BNP levels above the normal limit predict the development of pioglitazone-induced left ventricular dysfunction in patients with type 2 diabetes.
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Baseline BNP >18 pg/ml may identify T2D patients at risk for pioglitazone-associated LVD; leaves open need for prospective validation.
Ogawa et al. (2003) studied this question.