Why the study?
How arterial stiffness and sex interact at a molecular level to confer cardiovascular disease risk is not well understood.
Does MMP12 deletion or estrogen exposure reduce arterial stiffness and atherosclerosis in LDLR-null mice and macrophages?
Population
LDLR-null mice and human and mouse macrophages
Comparison
MMP12 deletion vs intact MMP12, and estrogen treatment vs control
Design
Preclinical animal and in vitro laboratory study
Authors
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MMP12 may mediate male-biased arterial stiffness in hypercholesterolemic mice; hypothesis-generating for human sex-specific therapies.
Does MMP12 deletion or estrogen exposure reduce arterial stiffness and atherosclerosis in LDLR-null mice and macrophages?
Estrogen protects against atherosclerosis in females by downregulating oxidized LDL-induced macrophage MMP12 secretion, thereby reducing arterial stiffness.
Liu et al. (2019) studied this question.
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