Population
Circadian clock-mutant mice (Bmal1-knockout [KO] and Per-triple KO) and wild-type mice
Comparison
Matrix metalloproteinase (MMP) inhibition vs Wild-type mice or no MMP inhibition
Design
Preclinical
Authors
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Circadian clock loss impairs arterial compliance in mice; hypothesis-generating for human vascular aging and should not yet change practice.
Circadian clock dysfunction contributes to arterial stiffening in mice, potentially through impaired regulation of matrix metalloproteinases.
Anea et al. (2010) studied this question.
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