Why the study?
Does hydrogen sulfide lower blood pressure via oxidative activation of PKG Iα in mice?
Does hydrogen sulfide lower blood pressure via oxidative activation of PKG Iα in mice?
Hydrogen sulfide lowers blood pressure through a paradoxical oxidative activation of PKG Iα, providing new mechanistic insights into endogenous blood pressure regulation.
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May guide redox-targeted antihypertensives; leaves open translation from murine models to human hypertension.
Stubbert et al. (2014) studied this question.
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