April 3, 2022Expert Opinion on Biological TherapyOpen Access

Addressing high dose AAV toxicity – ‘one and done’ or ‘slower and lower’?

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Abstract

KEYWORDS: Gene therapyadeno-associated virusAAV toxicityhepatotoxicitythrombotic microangiopathyhepatocellular carcinomadorsal root ganglia toxicityAAV capsid engineeringimmune tolerance

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Cite This Study

Kishimoto et al. (2022) studied this question.

synapsesocial.com/papers/6a02a4024f17ebd438650c20 https://doi.org/10.1080/14712598.2022.2060737

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Abstract

KEYWORDS: Gene therapyadeno-associated virusAAV toxicityhepatotoxicitythrombotic microangiopathyhepatocellular carcinomadorsal root ganglia toxicityAAV capsid engineeringimmune tolerance