Induction of Tumor Necrosis Factor in Human Peripheral-Blood Mononuclear Cells by Proteolytic Enzymes

We could demonstrate that polyenzyme preparations as well as bromelain and papain stimulate the production of tumor necrosis factor-alpha in human peripheral-blood mononuclear cell cultures in a time-dependent manner. We give evidence that immunomodulation and especially the release of cytokines may contribute to the therapeutic effect of these preparations.