Antidepressant use and risk of adverse outcomes in older people: population based cohort study

60,746 patients aged 65 to 100 years diagnosed with a new episode of depression in the United Kingdom.

Antidepressant treatment (selective serotonin reuptake inhibitors, tricyclic antidepressants, monoamine oxidase inhibitors, and other antidepressants including trazodone, mirtazapine, and venlafaxine)

Periods when antidepressants were not being used

All cause mortality, attempted suicide/self harm, myocardial infarction, stroke/transient ischaemic attack, falls, fractures, upper gastrointestinal bleeding, epilepsy/seizures, road traffic accidents, adverse drug reactions, and hyponatraemiasafety