What question did this study set out to answer?

To evaluate recent advancements in coupling reagents and clarify selection criteria for efficient amide bond synthesis.

December 4, 2008Chemical Society Reviews

Amide bond formation: beyond the myth of coupling reagents

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Authors

EVEric ValeurRoivant Sciences (United States)MBMark BradleyQueen Mary University of London

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Implication

Critical review reveals the trade-offs of modern acronym-based coupling reagents in organic synthesis, highlighting criteria for optimal amide bond formation.

Key Points

To evaluate recent advancements in coupling reagents and clarify selection criteria for efficient amide bond synthesis.
Critically reviewed 179 published literature sources examining contemporary coupling reagents.
Assessed the synthetic utility, pros, and cons of widely used acronym-based reagents in organic synthesis.
Cataloged the mechanistic profiles and practical drawbacks of numerous acronym-based coupling agents.
Established rational selection criteria to help chemists replace empirical trial-and-error with targeted reagent choices.

Cite This Study

Valeur et al. (2008) studied this question.

synapsesocial.com/papers/6a02afa067f6ea5cc8755695 https://doi.org/10.1039/b701677h

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Implication

Critical review reveals the trade-offs of modern acronym-based coupling reagents in organic synthesis, highlighting criteria for optimal amide bond formation.

Amide bond formation: beyond the myth of coupling reagents

Discussion

Member takes

Implication

Key Points

Cite This Study

Amide bond formation: beyond the myth of coupling reagents

Discussion

Member takes

Implication

Key Points

Cite This Study

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