What question did this study set out to answer?

To review the current literature on the pathophysiology, health outcomes, and risk factors of exertional heat stroke while identifying major gaps in knowledge.

October 1, 2022BMJ MedicineOpen Access

Exertional heat stroke: pathophysiology and risk factors

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To review the current literature on the pathophysiology, health outcomes, and risk factors of exertional heat stroke while identifying major gaps in knowledge.
Synthesized clinical and epidemiological literature examining exertional heat illnesses and exertional heat stroke.
Evaluated physiological mechanisms underlying thermoregulatory failure, multiorgan injury, and treatment responses.
Exertional heat stroke carries an estimated mortality rate of approximately 27%, with surviving patients experiencing long-term neurological and cardiovascular dysfunction.
Thermoregulatory and cardiovascular overload leads to profound hyperthermia, driving multiorgan injury via systemic inflammatory response syndrome and coagulopathy.
Identified risk factors include dehydration, biological sex differences, aging, body composition, and recent illness, with immediate cooling representing the most effective therapeutic intervention.

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Implication

Narrative review reveals the pathophysiology, mortality risks, and complications of exertional heat stroke in physically active individuals, highlighting the crucial need for immediate cooling.

Cite This Study

Garcia et al. (2022) studied this question.

synapsesocial.com/papers/6a02b5fff1675f581a754f20 https://doi.org/10.1136/bmjmed-2022-000239

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Implication

Narrative review reveals the pathophysiology, mortality risks, and complications of exertional heat stroke in physically active individuals, highlighting the crucial need for immediate cooling.

Exertional heat stroke: pathophysiology and risk factors

Key Points

Discussion

Implication

Cite This Study

Exertional heat stroke: pathophysiology and risk factors

Key Points

Discussion

Implication

Cite This Study

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