What question did this study set out to answer?

To assess the relationship between individual dietary antioxidant intake, the composite dietary antioxidant index (CDAI), and the risk of all-cause and cardiovascular mortality among individuals with cardiovascular disease.

April 9, 2025BMC Public HealthOpen Access

Association of independent dietary antioxidant intake, and CDAI level with risks of all-cause and cardiovascular-cause death among population with cardiovascular disease

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Cardiovascular disease (n=1395). Intervention: Higher composite dietary antioxidant index (CDAI) vs. First tertile (T1) of CDAI. Primary outcome: All-cause mortality (HR 0.62, 95% CI 0.46-0.85).

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Key result

Higher dietary antioxidant index linked to ~38% lower all-cause mortality in CVD.

HR 0.62
95% CI 0.46-0.85
n=1,395

Why the study?

Does higher dietary antioxidant intake reduce all-cause and cardiovascular mortality in patients with cardiovascular disease?

Population

1,395 participants with cardiovascular disease from the National Health and Nutrition Examination Survey

Comparison

Higher levels of dietary antioxidants vs Lower levels of dietary antioxidants

Design

Cohort

Authors

XHXintao HuXidian University ZZZhao ZhaoNanyang Institute of Technology QAQian AnQingdao University

Discussion

Member takes

Implication

Higher dietary antioxidant intake, measured by the composite dietary antioxidant index, is associated with significantly reduced risks of all-cause and cardiovascular mortality in patients with cardiovascular disease.

Key Points

To assess the relationship between individual dietary antioxidant intake, the composite dietary antioxidant index (CDAI), and the risk of all-cause and cardiovascular mortality among individuals with cardiovascular disease.
Analyzed 1,395 participants with cardiovascular disease from the National Health and Nutrition Examination Survey (2001–2010).
Calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for individual antioxidants (vitamins A, C, E, selenium, carotenoids, zinc) and CDAI using Cox proportional hazards models.
Evaluated potential non-linear relationships using restricted cubic splines (RCS).
Higher intakes of individual vitamins C and E were inversely associated with both all-cause and cardiovascular mortality.
Compared to the lowest tertile (T1), the highest CDAI tertile (T3) demonstrated significantly reduced risks of all-cause mortality (HR 0.62, 95% CI: 0.46–0.85) and cardiovascular mortality (HR 0.58, 95% CI: 0.35–0.97).
Restricted cubic spline modeling showed a linear association between CDAI and all-cause mortality, but an inverted L-shaped non-linear relationship for cardiovascular death.

Study Design

Type

Cohort (n=1,395)

Multicenter

Yes

Structured PICO

Does higher dietary antioxidant intake reduce all-cause and cardiovascular mortality in patients with cardiovascular disease?

Population

1,395 participants with cardiovascular disease from the National Health and Nutrition Examination Survey (2001-2010).

Exposure

Higher levels of dietary antioxidants (individual antioxidants including vitamins A, C, E, selenium, carotenoids, zinc, and composite dietary antioxidant index [CDAI])

Comparator

Lower levels of dietary antioxidants (e.g., first tertile of CDAI)

Outcome

All-cause mortality and cardiovascular deathhard clinical

Main Result

Hazard Ratio: 0.62 (95% CI 0.46–0.85)

Cite This Study

Hu et al. (2025) conducted a cohort in Cardiovascular disease (n=1,395). Higher composite dietary antioxidant index (CDAI) vs. First tertile (T1) of CDAI was evaluated on All-cause mortality (HR 0.62, 95% CI 0.46-0.85). Higher composite dietary antioxidant index (third vs first tertile) was associated with reduced all-cause mortality (HR 0.62; 95% CI 0.46-0.85) in patients with cardiovascular disease.

synapsesocial.com/papers/6a02bb1375054b3fdf9e2044 https://doi.org/10.1186/s12889-025-22481-1

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Association of independent dietary antioxidant intake, and CDAI level with risks of all-cause and cardiovascular-cause death among population with cardiovascular disease

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Association of independent dietary antioxidant intake, and CDAI level with risks of all-cause and cardiovascular-cause death among population with cardiovascular disease

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider