What question did this study set out to answer?

The study aims to formulate a hybrid nanoemulsion of β-arbutin and C. asiatica extract to inhibit melanogenesis effectively.

May 12, 2026Tropical Journal of Natural Product ResearchOpen Access

Centella asiatica Extract and Arbutin Hybrid Nanoemulsion as a Synergistic Inhibitor of Melanogenesis

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The study aims to formulate a hybrid nanoemulsion of β-arbutin and C. asiatica extract to inhibit melanogenesis effectively.
Formulated a hybrid nanoemulsion combining β-arbutin and asiaticoside from Centella asiatica.
Conducted bioinformatics analysis and molecular docking to validate gene targets involved in melanogenesis.
Characterized the hybrid nanoemulsion for physicochemical stability and tested its tyrosinase inhibition and melanin suppression in B16F10 melanoma cells.
The optimized hybrid nanoemulsion exhibited nanosized droplets (10.44 ± 0.28 nm) and high tyrosinase inhibition at 91.54 ± 0.77%.
Intracellular melanin production was significantly reduced by 13.08 ± 2.02% compared to single formulations, indicating enhanced anti-melanogenic activity.
Binding affinities with tyrosinase for asiaticoside (−6.38 kcal/mol) and β-arbutin (−6.23 kcal/mol) were confirmed.

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Implication

Randomized trial demonstrates synergy in inhibiting melanin production using a novel nanocarrier in melanoma cells, implying potential for skin lightening therapies.

Cite This Study

Wibowo et al. (2026) studied this question.

synapsesocial.com/papers/6a02c2b9ce8c8c81e96402cf https://doi.org/10.26538/tjnpr/v10i4.73

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Implication

Randomized trial demonstrates synergy in inhibiting melanin production using a novel nanocarrier in melanoma cells, implying potential for skin lightening therapies.

Centella asiatica Extract and Arbutin Hybrid Nanoemulsion as a Synergistic Inhibitor of Melanogenesis

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Discussion

Implication

Cite This Study

Centella asiatica Extract and Arbutin Hybrid Nanoemulsion as a Synergistic Inhibitor of Melanogenesis

Key Points

Discussion

Implication

Cite This Study

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