Why the study?
An increasing number of BAV patients are undergoing TAVR, but the risk of brain injury on DW-MRI was unknown.
Does TAVR in bicuspid aortic valve patients increase the risk of brain injury on DW-MRI compared to tricuspid aortic valve patients?
Does TAVR in bicuspid aortic valve patients increase the risk of brain injury on DW-MRI compared to tricuspid aortic valve patients?
Answers are grounded in this paper and cite their sources.
Patients with bicuspid aortic valves undergoing TAVR have a significantly higher risk of early brain injury detected by DW-MRI compared to those with tricuspid aortic valves.
BACKGROUND: An increasing number of bicuspid aortic valve (BAV) patients are undergoing transcatheter aortic valve replacement (TAVR), but the risk of brain injury in diffusion-weighted magnetic resonance imaging (DW-MRI) is currently unknown. OBJECTIVES: This study sought to evaluate the risk of brain injury in BAV patients following TAVR. METHODS: A total of 204 consecutive severe aortic stenosis patients who underwent TAVR were enrolled. A total of 83 (40.7%) patients were BAV patients, and the other 121 patients were tricuspid aortic valve (TAV) patients. All patients received DW-MRI at baseline, and after TAVR. RESULTS: (28.6% vs. 10.9%; p = 0.005) was higher in BAV patients than in TAV patients. CONCLUSIONS: BAV patients may encounter more severe brain injuries not only due to greater number of lesions, but also due to larger lesion size in the early phase after TAVR. (Transcatheter Aortic Valve Replacement Single Center Registry in Chinese Population [TORCH]; NCT02803294).
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Fan et al. (2020) studied this question.
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