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Demonstrates that lower myelin content correlates with faster executive and memory decline in cognitively intact adults, suggesting myelin MRI measures may serve as predictive biomarkers.
INTRODUCTION: The influence of myelination on longitudinal changes in cognitive performance remains unclear. METHODS: ); both are MRI measures sensitive to myelin, with MWF being specific. RESULTS: was associated with steeper declines in executive function (p < .02 in all regions) and memory (p < .04 in occipital and cerebral white matter) but did not survive Bonferroni correction. DISCUSSION: as imaging biomarkers to predict cognitive changes.
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Gong et al. (2023) studied this question.
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