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Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-γ

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The aim is to investigate the role of PPAR-gamma in mediating the antiinflammatory effects of 5-ASA in colitis.
Induced colitis in PPAR-gamma(+/-) and wild-type mice
Administered 5-ASA treatment
Checked PPAR-gamma expression and activity in epithelial cells
5-ASA treatment improved colitis in wild-type mice only, suggesting dependence on PPAR-gamma.
5-ASA increased PPAR-gamma expression and promoted its nuclear translocation in epithelial cells.
PPAR-gamma activation led to the recruitment of coactivators and gene activation.

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Randomized trial shows the role of PPAR-gamma in mediating the antiinflammatory effects of 5-ASA in colitis, suggesting a new target for treatment.

Rousseaux et al. (2005) studied this question.

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Randomized trial shows the role of PPAR-gamma in mediating the antiinflammatory effects of 5-ASA in colitis, suggesting a new target for treatment.