What question did this study set out to answer?

The aim is to identify existing drugs suitable for prostate cancer treatment and assess their efficacy.

April 8, 2011Cancer DiscoveryOpen Access

A Novel Two-Stage, Transdisciplinary Study Identifies Digoxin as a Possible Drug for Prostate Cancer Treatment

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Randomized trial investigates digoxin's effect on prostate cancer risk in men, suggesting its potential use as a treatment.

The aim is to identify existing drugs suitable for prostate cancer treatment and assess their efficacy.
Conducted an in vitro cytotoxicity screen of 3,187 compounds for prostate cancer cells.
Evaluated the association between digoxin use and prostate cancer risk in 47,884 men from 1986 to 2006.
Monitored digoxin users and non-users for long-term effects on prostate cancer incidence.
Regular digoxin users demonstrated a reduced prostate cancer risk (RR=0.76, 95% CI 0.61-0.95).
Long-term users of digoxin (≥ 10 years) showed an even lower risk (RR=0.54, 95% CI 0.37-0.79, P-trend<0.001).
Digoxin inhibited prostate cancer cell growth with a potent in vitro mean IC₅₀ of 163 nM.

Platz et al. (2011) studied this question.

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