Why the study?
Do antidiabetic sulfonylureas (glibenclamide) restore action potential properties in ATP-depleted cardiac cells?
Do antidiabetic sulfonylureas (glibenclamide) restore action potential properties in ATP-depleted cardiac cells?
Sulfonylureas like glibenclamide restore action potentials in ATP-depleted cardiac cells by blocking ATP-sensitive K+ channels, demonstrating a direct electrophysiological effect on the heart.
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Should not change clinical practice in ischemia; leaves open KATP channel effects in human cardiac electrophysiology.
Fosset et al. (1988) studied this question.
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