In Silico Prediction of Human Intravenous Pharmacokinetic Parameters with Improved Accuracy

= 0.291). Assessed by 10-fold cross validation, leave-one-out cross validation, Y-randomization test and applicability domain evaluation, these models demonstrated excellent stability and predictive ability. Compared with other published models for human pharmacokinetic parameters estimation, it was further confirmed that our models obtained better predictive ability and could be used in the selection of preclinical candidates.