Irradiated sporozoite vaccination induces sex-specific immune responses and protection against malaria in mice

This is the authors' abstract. We don't add key points for this paper.

T cells isolated from the liver, and protection following parasite challenge. Conversely, depletion of sex steroids in female mice did not alter vaccine-induced responses or protection following challenge. These data suggest that elevated testosterone concentrations in males reduce adaptive immunity and contribute to sex differences in malaria vaccine efficacy.