What question did this study set out to answer?

This research aims to understand the cellular origins of fibrotic lesions in pulmonary fibrosis and examine the roles of stromal populations.

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

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Experimental analysis reveals stromal cell roles in pulmonary fibrosis, highlighting novel cellular contributions.

This research aims to understand the cellular origins of fibrotic lesions in pulmonary fibrosis and examine the roles of stromal populations.
Analyzed normal and fibrotic mouse and human lung tissue using confocal microscopy.
Tracked the fate of pericyte-like cells and Type II alveolar cells in the bleomycin-induced pulmonary fibrosis model using genetic tools.
Examined cell lineage and molecular markers to determine origins of myofibroblasts.
Identified unexpected heterogeneity in stromal cells with characteristics of pericytes that proliferate in fibrotic regions.
Demonstrated that neither pericytes nor labeled epithelial cells transition to myofibroblasts, as indicated by low expression of Acta2.
Showed that bleomycin accelerates the conversion of Type II alveolar cells to Type I, rather than to myofibroblasts.

Rock et al. (2011) studied this question.

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