High-potency ligands for DREADD imaging and activation in rodents and monkeys

Jordi Bonaventura; Mark A. G. Eldridge; Feng Hu; Juan L. Gomez; Marta Sánchez‐Soto; Ara M. Abramyan; Sherry Lam; Matthew A. Boehm; Christina M. Ruiz; Mitchell R. Farrell; Andrea Moreno; Islam Faress; Niels Andersen; John Y. Lin; Ruin Moaddel; Patrick J. Morris; Lei Shi; David R. Sibley; Stephen V. Mahler; Sadegh Nabavi; Martin G. Pomper; Antonello Bonci; Andrew G. Horti; Barry J. Richmond; Michael Michaelides

doi:10.1038/s41467-019-12236-z

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Abstract

F]JHU37107 combined with PET allows for DREADD detection in locally-targeted neurons, and at their long-range projections, enabling noninvasive and longitudinal neuronal projection mapping.

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synapsesocial.com/papers/6a031141c8c4199b329e3907 https://doi.org/10.1038/s41467-019-12236-z

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High-potency ligands for DREADD imaging and activation in rodents and monkeys

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High-potency ligands for DREADD imaging and activation in rodents and monkeys

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