Why the study?
Does chronic renin-angiotensin blockade with losartan and enalaprilat improve sympathetic reactivity and beta-adrenergic signaling in spontaneously hypertensive rats?
Does chronic renin-angiotensin blockade with losartan and enalaprilat improve sympathetic reactivity and beta-adrenergic signaling in spontaneously hypertensive rats?
Renin-angiotensin blockade with losartan and enalaprilat normalizes sympathetic hyperreactivity and beta-adrenergic signaling in spontaneously hypertensive rats, suggesting a mechanism for their antihypertensive action.
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Hypothesis-generating in SHR; human studies needed to assess sympathetic effects of renin-angiotensin blockade.
Laflamme et al. (1997) studied this question.
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