Population
Human adrenal cross-sections, cultured adrenocortical cells, and in vivo models of obesity, leptin infusion…
Comparison
Leptin exposure vs Leptin deficiency, leptin receptor deficiency…
Design
Preclinical
Authors
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Hypothesis-generating in animals; human studies needed to assess relevance to obesity-related cardiovascular disease.
Leptin acts directly on adrenal glomerulosa cells to stimulate aldosterone production, providing a mechanistic link between obesity, hyperaldosteronism, and cardiovascular dysfunction.
Huby et al. (2015) studied this question.
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